Impaza is a drug based on ultra-low doses of antibody against endothelial NO-synthase and used for the treatment of various forms of erectile dysfunction.
The drug is presented in a very convenient form (orodispersible tablets).
By its pharmacological properties, Tenoten belongs to the group of anxiolytic and nootropic drugs, although its action is not limited to these two effects. In addition, in the experimental models of intoxication, hypoxy, or transient ischaemic attack, it demonstrated neuroprotective action, limiting the zone of cerebral damage. In the clinical studies, Tenoten administration restored cognitive functions and memory.
The mechanisms of these effects have been elucidated: antibodies against S-100 protein at ultra-low doses exert GABA-mimetic and neurotrophic actions, up-regulate stress-limiting systems, contribute to the restoration of neuroplasticity.
This broad spectrum of Tenoten pharmacological activity allows its successful use in various functional disorders and organic diseases of the central nervous system. Tenoten is indicated in the following functional disorders: neurotic and neurosis-like disorders; psychosomatic diseases; stress-induced disorders with increased tension, irritability, anxiety, and autonomic reactions. Clinical studies confirmed beneficial effects of Tenoten on mild to moderate organic CNS disorders, including those of traumatic or dyscirculatory etiology, with emotional lability, irritability, memory decline, and autonomic disorders.
Dosage and frequency regimen is chosen based on the intensity and duration of clinical symptoms. One or two tablets should be administered at a time (tablets are to be held in the mouth until their complete dissolution; not to be taken with food). In mild to moderate conditions, the drug is taken twice daily; when the symptoms are more intense, up to 4 times daily. Therapy regimen is also dependent on the duration and course of the disease: the drug is usually prescribed for 1 to 3 months; if necessary, therapy may be prolonged up to 6 months or repeated after 1-2 months.
The technology of ultra-low doses used in the manufacturing process significantly reduces the risk of adverse effects. Generally, they are possible only in individuals with hypersensitivity to any component of the tablet – lactose, microcrystalline cellulose, magnesium stearate. No cases of overdosage have been reported so far.